Retrospective Review of Traditional Chinese Medicine Treatment of COVID-19 in China: Clinical Practice and Researches
Keywords:COVID-19, TCM, Acupuncture, Integration of Chinese and Western Medicine
In the fight against COVID-19 in China, traditional Chinese medicine (TCM) has played an important role in relieving symptoms, preventing deterioration, improving cure rate, reducing death rate, and promoting recovery. Since the third edition of the Diagnosis and Treatment Protocol for COVID-19 (simply referred to as the National Protocol), TCM has been included in the national guidance to tackle the epidemic. In order to make the international medical community fully understand the experience of TCM in the prevention and treatment of COVID-19, we comprehensively reviewed the history, etiology and pathogenesis, prevention and treatment, rehabilitation, and clinical and pharmacological research of TCM used in the endemic. The COVID-19 is under the category of plague or pestilence in TCM. Herbal medicine treatment for COVID-19 is mainly performed based on the syndrome differentiation of three stages and four types. The method also applies to acupuncture and moxibustion treatments. Herbal medicine granules and injections are used flexibly, and Western medicine is adopted to rescue patients in critical conditions. In rehabilitation, the integration of Chinese and Western medicine can be used to improve the respiratory and somatic function of patients. The role TCM has been playing in fighting this epidemic is a further proof of the effect of TCM in preventing and treating infectious diseases, and the relevant experience has been summarized and sublimated.
Alturki SO, Alturki SO, Connors J, Cusimano G, Kutzler MA, Izmirly AM, et al. The 2020 pandemic: current SARS-cov-2 vaccine development. Front Immunol, 2020, 11: 1880.
WHO Coronavirus Disease (COVID-19) Dash-board.https://covid19.who.int,October 20, 2020. /October 20, 2020.
Huang XQ, Zhou MY, Cheng YR, Ye L, Wang MW, Chen J, et al. Opportunities and challenges of traditional Chinese medicine going abroad for COVID-19 treatment. Am J Emerg Med, 2020, S0735-6757(20)30 489 -7
Luo H, Tang QL, Shang YX, Liang SB, Yang M, Robinson N, et al. Can Chinese medicine be used for the prevention of coronavirus disease 2019 (COVID-19)? A review of historical classics, research evi-dence, and current prevention programs. Chin J Integrat Med, 26:243–250.
Wang W, Wang YW, Ma S, Li RF. Analy-sis on strategy, participation rate and cure effect of traditional Chinese medicine in treating covid-19 in 23 provinces (munic-ipalities and autonomous regions). World Chin Med,2020, 15(6):813-818.
Luo L, Jiang J, Wang C, Fitzgerald M, Hu W, Zhou Y, et al. Analysis on herbal medi-cines utilized for treatment of COVID-19. Acta Pharmaceutica Sinica B, 2020,10 (7):1192-1204.
Shi SF, Liu QQ. On TCM value in treat-ment to C OVID-19 based on TCM model of Jiangxia Cabin Hospital. Jiangshu J Tradit Chin Med, 2020, 52(4):11-14.
Chen RS, Wang JH, Shi Z. Analysis and thinking of tcm diagnosis and treatment protocol for COVID-19. Jiangshu J Tradit Chin Med, 2020, 52(4):60-64.
Zhang H, Luo L, Liu ZQ, Xie H. Retro-spektive auf die Prävention und Therapie von Covid-19 mit Chinesischer Medizin in China. Chin Med, 2020, 35(3):129-142.
Peng B, Wang SC, Gao TT, Zhang HL, Zhang J, Li J. Treatment of the new coro-navirus pneumonia caused by inflamma-tory storm from the perspective of damp-ness toxin complicated by wind. World Chin Med, 2020,15(03):315-319.
Hon KL, Leung KK, Leung AK, Qian SY, Chan VP, Ip P, et al. Coronavirus disease 2019 (COVID-19): latest developments in potential treatments. Drugs Context, 2020, 9:2020-4-15.
Hou ZJ, Zhang JH, Zhang X, Ling QH, Zheng C, Zhu XJ, et al. Long-term Tradi-tional Chinese Medicine combined with NA antiviral therapy on cirrhosis inci-dence in chronic hepatitis B patients in the real-world setting: a retrospective study. Evid Based Complement Alternat Med. 2020, 2020: 3826857.
Zhang JL, Li WX, Li Y, Wong MS, Wang YJ, Zhang Y. Therapeutic options of TCM for organ injuries associated with COVID-19 and the underlying mechanism. Phytomedicine, 2020:153297.
Luo H, Gao Y, Zou J, Zhang S, Chen H, Liu Q, et al. Reflections on treatment of COVID-19 with traditional Chinese medi-cine. Chin Med, 2020, 15(1):1-4.
Huang XQ, Nie LH, Li FM, Wang C, Cheng G, Cai KK, et al. Analysis of chinese medical characteristics of 35 patients with novel coronavirus pneumonia. J Emerg Tradit Chin Med, 2020, 29(3):383,398.
Zhou J, Chen JJ, Zhang NZ, Zhu XX, Li J, Wang Shi Q, et al. Investigation and Analysis of Traditional Chinese Medicine Syndromes with 144 Cases of COVID-19 Patients in Anhui Province. Zhongguo Shi Yan Fang Ji Xue Za Zhi, 2020, 26(12):28-34.
Pan XQ, Hu Z. Analysis on Chinese medical clinical characteristics of 64 pa-tients with common type COVID-19. J Wenzhou Med Univ, 2020,50(03):187-190.
Yang XN, Deng J, Li XF, Fang CX, Gong Y, Wang YL, et al. Distribution of tradi-tional Chinese medicine syndromes in children with coronavirus disease 2019: an analysis of 11 cases. J Guangzhou Univ Tradit Chin Med, 2020,37(06):1008-1011.
Liu B, Wang H, Zhou ZY, Chang XR, Zhang W, Liu BY. Analysis on the theory and clinical ideas of acupuncture and moxibustion for the prevention and treatment of coronavirus disease 2019. Zhongguo Zhen Jiu, 2020, 40(6):571-575.
Zhang B, Zhang K, Tang Q, Sun K, Han Z. Acupuncture for breathlessness in COVID-19: A protocol for systematic re-view and meta-analysis. Medicine (Balti-more). 2020, 99(27): e20701.
Jia H, Han Z, Zhang K, Tang Q, Sun K, Huang H, et al. Acupuncture and related interventions for anxiety in coronavirus disease 2019: A protocol for systematic review and meta-analysis. Medicine (Bal-timore). 2020, 99(30): e21317.
Huang KY, Chang CH, Hsu CH. The efficacy of acupuncture for improving the side effects of COVID-19 western medi-cine treatments: A protocol for a system-atic review and meta-analysis. Medicine (Baltimore). 2020 Jul 10;99(28): e21185.
Liu WH, Guo SN, Wang F, Hao Y. Un-derstanding of guidance for acupuncture and moxibustion interventions on COVID-19 (Second edition) issued by CAAM. World J Acupunct Moxibustion, 30(1):1-4.
Huang XB, Xie DY, Qiu Q, Shen Y, Jiao L, Li QL, Chen RX. Clinical observation of heat-sensitive moxibustion treatment for coronavirus disease 2019. Zhongguo Zhen Jiu, 2020, 40(6):576-580.
Wuhan Health Commission. Wuhan recommendation program of home pre-vention for covid-19. http://wjw.wuhan.gov.cn /ztzl_28/fk/tzgg/202004/t20200430_1197335.shtml. Feb. 1, 2020/October 20, 2020.
Chen G, Liu YJ. The TCM treatment and prevention guideline for COVID-19 by Tongji Hospital, Huazhong University of Science and Technology. Herald Med, 2020, 3:308-309.
Carmassi C, Foghi C, Dell'Oste V, Cordone A, Bertelloni CA, Bui E, et al. PTSD symptoms in healthcare workers facing the three coronavirus outbreaks: What can we expect after the COVID-19 pandemic. Psychiatry Res, 2020,292:113312.
Xia WG, Hua Q, Wang G, Guo TC, Zhu SS, Zhao Y, et al. Standard for rehabilita-tion diagnosis and treatment of COVID-19 with integration of Traditional Chinese and Western Medicine. Rehabil Med, 2020, 30(2):94-101.
Song P, Zhao L, Li X, Su J, Jiang Z, Song B, et al. Interpretation of TCM part in di-agnosis and treatment protocol for COVID-19 (trial version 7). J Tradit Chin Med, 2020,40(3):497-508.
Zhang Y, Wang YG, Chen HY. Thinking and methods of TCM rehabilitation treat-ment for discharged patients with novel coronavirus pneumonia. Beijing J Univ Tradit Chin Med, 2020,39(3):227-229.
Kantatong T, Panpanich R, Deesom-chok A, Sungkarat S, Siviroj P. Effects of the tai chi qigong programme on function-al capacity, and lung function in chronic obstructive pulmonary disease patients: A ramdomised controlled trial. J Tradit Com-plement Med. 2020, 10(4):354-359.
Ding M, Zhang W, Li K, Chen X. Effec-tiveness of t'ai chi and Qigong on chronic obstructive pulmonary disease: a system-atic review and meta-analysis. J Alternat Complement Med, 2014, 20(2):79-86.
Zhang H. Bamai Qigong. Aarhus, Heyttu Academic Publishing, 2020:13-16.
Xu EP, Xu JY, Xu LR, Wei Z, Meng PF, Song XY, et al. Outline of Classical Pre-scriptions on Differentiation and Treat-ment of Common Disease Symptoms of COVID-19. Acta Chin Med, 2020, 35(4):679-681.
Ba YM, Li XD, Min XJ, Chen YG, Yang Y, Tao R, et al. Novel coronavirus pneumonia in Hubei provincial hospital of TCM: a Chinese medicine prevention and treat-ment plan (Third Edition). Hubei J Tradit Chin Med, 2020,42(2):7-8.
Sichuan Administration of Traditional Chinese Medicine. No.1,2,3 Formulae ap-proved to apply in 205 hospitals within Sichuan province. http://www.nbd.com.cn/articles/2020-02-12/1407710.html, Feb. 12, 2012/October 20, 2020.
Duan C, Xia WG, Sun GB, Li ZL, Li QL, Li P, et al. Clinical observation on Jinhua Qinggan Granule (金花清感颗粒) combined with conventional western medicine therapy in treating mild cases of coron-avirus disease 2019.J Chin Med, 2020, 2020,61(17):1473 -1477.
Yang ZJ, Ye L, Chen L, Miao MS, LI YJ. Treatment of COVID-19 with Qi Gui Ling mixture. Acta Chin Med, 2020, 35(6):1151-1153,1179.
Chen L, Cheng ZQ, Liu F, Chen YG. Analysis of 131 cases of COVID-19 treat-ed with Ganlu Xiaodu Decoction. China J Chin Materia Medica, 2020, 45(10):2232-2238.
Xie YF, Ruan YD, Liu XR, Zhuang XM. Discussion on experience of traditional chinese medicine in treating 8 cases of severe new coronavirus pneumonia. J Pract Tradit Chin Intern Med, 2020, 34(8):1-3,5.
Wu H, Xia L, Sun YS, Shi MY, Xu GH, Li K, et al. Application of TCM purgative method to COVID-19 treatment. Shanghai J Tradit Chin Med, 2020, 54(6):12-15.
Shanghai Covid-19 Medical Expert Team. Shanghai Expert Consensuson the Treatment of COVID-19. http://rs.yiigle.com/yufabiao/1183266.htm.Oct.20/Oc tober 20, 2020.
Kang L, Miao JX, Miao MS, Zhang YN, Zhang J. Function Characteristics of Xuebijing in the Treatment of COVID-19. Pharmachol Clin Chin Materia Medica, 2020, 36(2):11-15.
Kong Y, Wu HW, Chen Y, Lai S, Yang ZM, Chen JS. Mechanism of Tanreqing Injection on treatment of coronavirus disease 2019 based on network pharma-cology and molecular docking. Chin Tradit Herbal Drug, 2020,51(7):1785-1794.
Zhao J, Tian SS, Yang J, Liu JF, Zhang WD. Investigating mechanism of Qing-Fei-Pai-Du-Tang for treatment of COVID-19 by network pharmacology. Chin Tradit Herbal Drug, 2020, 51(04): 829-835.
Wang FC, Shen BX, He CY, Zhao WC, Nie SL. Clinical efficacy of Lianhua Qingwen Granules and its mechanism on COVID-19 based on network pharmacol-ogy. Pharmacol Clin Chin Materia Medica, 2020, 36(2):93-101.
Simayi J, Noormaimaiti M, Wumaier A, Yusufu M, Noor M, Mahemuti N, et al. Study on the active components in the adjuvant treatment of novel coronavirus pneumonia (COVID-19) with Jinhua Qinggan Granules based on network pharmacology and molecular docking. J Chin Med Mater, 2020, 5:1275-1283.
Li JJ, Zhang K, Wang SS, Jing WL, Bao JM, Yang JY, et al. Network pharmacology for treatment of COVID-19 with Renshen Baidu Powder based on cytokines. Chin Tradit Herbal Drug, 2020, 51(7):1677-1684.
Sun KB, Zhang XY, Liu J, Sun R. Net-work pharmacological analysis and mechanism prediction of Xiaochaihu De-coction in treatment of COVID-19 with syndrome of pathogenic heat lingering in lung and obstructive cardinalate. Chin Tradit Herbal Drug, 2020,51(7):1750-1760.
Chen X. Zhang Boli, establish TCM system to prevent and treat epidemic dis-eases. http://stdaily.com/index/fangtan/2020-06/ 08/content_953702.shtml,Jun.8, 2020/October 18, 2020.
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